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Diphenhydramine (Benadryl) for Children

  • Do not use with other cold/cough medications other than Ibuprofen or Acetaminophen.
  • We do not recommend Benadryl combined with a decongestant.
  • Most commonly used during illness for sleep.
  • Do not use more than every 6 hours or as directed by your pediatrician.
  • Benadryl should not be given if the child has marked decreased activity, lethargy, or appears ill.  If your child has these symptoms, please contact your pediatrician.

and Age

Children’s Benadryl
12.5mg/ 5mL Suspension

Children’s Benadryl
12.5mg Chewable Tablet

Under 2 Years

Consult your pediatrician

Do not use

24-35 lbs.

2-3 Years

5mL (1 tsp.)

1 Tablet

36-47 lbs.

4-5 Years

7.5mL (1 ½ tsp.)

1 ½ Tablets

48-59 lbs.

6-8 Years

10mL (2 tsp.)

2 Tablets

60-71 lbs.

9-10 Years

12.5mL (2 ½ tsp.)

2 ½ Tablets

72-95 lbs.


15mL (3 tsp.)

3 Tablets

mL = milliliters, tsp. = teaspoon